/COMUNICAE/
MAR luminous: oxidative stress can result from different harmful factors, sometimes difficult to detect, affecting both testicles and ovaries. Its effects are multiple, such as causing fertilization problems, blocking the pre-plantation development of embryos, causing the failure of the process of implantation (anidation) of embryos in the uterus, and significantly raising the risk of involuntary abortions and anomalies in the offspring.
In women, oxidative stress is often caused by poor diet and sedentary life. In other cases, the main cause is endometriosis. In addition, some genetic problems cause predisposition to premature ovarian aging.
In man, genetic and epigenetic problems, alcohol and drug abuse, bad eating habits, sedentarism, as well as a professional exposure to toxic substances are highlighted. However, the deterioration of sperm is slower compared to that of the eggs.
How to combat it
To counteract the harmful effects of oxidative stress, several drugs with an antioxidant effect can be used. Among those with a direct effect are vitamins C and E, folic acid, coenzyme Q10 and, above all, melatonin, the strongest of all. In addition to combining direct and indirect antioxidant effects, melatonin slows the development of endometriosis and adenomiosis, and acts as an anti-inflammatory and immunomodulator that increases resistance against viral diseases, including different variants of COVID-19. The growth hormone acts in the same sense, but only in an indirect way, activating the antioxidant mechanisms of the organism.
All these medicines are being used to improve fertility, both in men and in women. However, an incorrect choice of the medication used and the dose applied may have counterproductive effects on people of both sexes.
In an article published by the directors of the clinic of Granada, Dr. Jan Tesarik and Dr. Raquel Mendoza Tesarik, in the magazine International Journal of Molecular Sciences, different genes are listed whose anomalies can cause this phenomenon. Another article by Dr. Tesarik, published in the journal Biomedicines, highlights the risks of uncontrolled use of different antioxidant drugs.
According to the Granada scientist, it is important to emphasize that the use of all these drugs would have to be controlled by a doctor specializing in assisted reproduction to choose the optimal combination and avoid excesses in dosing.
“The most successful thing is to have as full knowledge as possible of the condition of the two members of the couple with a fertility problem, before deciding whether the use of antioxidant drugs is advisable and, if any, what is the medicine chosen and its proper dose. The decision corresponds to the specialist and it is always necessary to avoid self-medication, which can have unpredictable effects,” says Dr. Jan Tesarik and Dr. Raquel Mendoza-Tesarik.
oxidative stress: “invisible” enemy of fertility
MAR luminous: oxidative stress can result from different harmful factors, sometimes difficult to detect, affecting both testicles and ovaries. Its effects are
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2023-04-11
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