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Researchers of the CSIC, together with universities and hospitals and using Artificial Intelligence, will study the effects of nutrition and lifestyle on a rising disease that in Spain already affects 300 thousand Spanish
A series of researchers from the CSIC, in collaboration with several Spanish universities and hospitals, have initiated a pioneer project to study with Artificial Intelligence the effect of nutrition and lifestyle on the microbiota and its beneficial effect on the treatment and control of Intestinal Inflammatory Disease (IIB). The project is inspired by the actual experience of one of the team's researchers, who has been a patient of ulcerative colitis since 1992. “Because of my passion for intensive sports practice (running and mountaineering) and my patient status with ISIS, over the years I have been forced to ‘learn’ to eat better and consciously. Over time, I think good nutrition and a healthy lifestyle have helped me a lot in the long-term evolution of my disease. Now, through this research consortium we want to turn this belief into scientific evidence to help others,” explains David García.
Background
IBS, which encompasses Crohn's disease and ulcerative colitis, is a chronic and recurrent autoimmune inflammatory disorder of the gastrointestinal tract that affects 7 million people around the world, with an upward trend. In Spain alone it is estimated that there are about three hundred thousand patients. The inflammatory process involves ulceration and bleeding of the tissues that cover the intestines, which can cause various symptoms, such as abdominal pain, involuntary weight loss, diarrhea, rectal bleeding, and fever. Sometimes other conditions also occur, such as arthritis and anemia. Symptoms may be mild or severe. Most people with IBS experience periods of good health followed by times when their symptoms are exacerbated and may require hospital admission and surgery.
Although the mortality rate by age is relatively low and has even been reduced in recent years, the non-lethal burden is enormous and continues to increase. The impact on health systems and economies is enormous because standard care for chronic diseases such as IIA is extremely costly, due to factors such as the use of expensive medicines, hospitalizations, surgery, and other medical conditions associated with IIA, such as anemia or psychiatry.
New therapies
As of today, the cause of the disease remains unknown, so current treatments are more oriented to treat symptoms than the cause. IIB's current therapy focuses on suppressing the immune system response, which involves significant risks and unwanted side effects. In addition, the incomplete effectiveness of current drugs invites to develop and use other therapies. The research of microbiota supported in data and artificial intelligence (IA) is a field of growing development and interest that has already demonstrated significant successes in the field of health. Ascension Marcos, director of the CSIC Immunonutrition Group, explains the team's working hypothesis: “The objective is to carry out a comprehensive intervention in the diet and lifestyle to achieve a greater diversity of food and nutrients in daily intake.”
Impact
If the team hypothesis is confirmed, the benefits of the project would be enormous. According to Felipe Lombó, professor at the University of Oviedo and coordinator of the Biotechnology Research Group in Nutraceutics and Bioactive Compounds-BIONUC, "a better control of the disease would be obtained, with a reduction of the most costly components of ISIS care. Dietary intervention would not mean a higher cost for health systems or for patients, but a better nutritional education. We would reduce long-term complications of IBS, such as colorectal cancer induced by ulcerative colitis. And we would increase the quality of life of patients.”
Start a pioneer project that aims to control Intestinal Inflammatory Disease
Researchers of the CSIC, together with universities and hospitals and using Artificial Intelligence, will study the effects of nutrition and lifestyle on a ris
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2023-04-11
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